The Pelling Lab

University of Ottawa

Department of Physics

STEM Complex

150 Louis Pasteur

Ottawa, ON K1N6N5

Canada

  • Twitter - Grey Circle
  • Instagram - Grey Circle

Copyright © 2017 Pelling Lab

Publications

JOURNAL ARTICLES 

63. Hickey, R.J. & Pelling, A.E. Cellulose Biomaterials for Tissue Engineering. Front Bioeng Biotechnol 7, 45 (2019) [Link]

 

62. Campuzano, S. & Pelling, A.E. Scaffolds for 3D Cell Culture and Cellular Agriculture Applications Derived From Non-animal Sources. Front Sustain Food Syst 3, 38 (2019) [Link]

61. Singh, G.G., Farjalla, V.F., Chen, B., Pelling, A.E., Ceyhan, E., Dominik, M., Alisic, E., Kerr, J., Selin, N.E., Bassioni, G., Bennett, E., Kemp, A.H. & Chan, K. Researcher engagement in policy deemed societally beneficial yet unrewarded. Front Ecol Environ 17, 375 (2019) [Link]

60. Chagnon-Lessard, S., Godin, M. & Pelling, A.E. Time dependence of cellular responses to dynamic and complex strain fields. Integr Biol 11, 4 (2018) [Link]

59. Hickey, R.J., Modulevsky, D.J., Cuerrier, C.M. & Pelling, A.E. Customizing the Shape and Microenvironment Biochemistry of Biocompatible Macroscopic Plant-Derived Cellulose Scaffolds. ACS Biomater Sci Eng 4, 3726 (2018) [Link].

 

58. Walker, M.J., Godin, M. & Pelling, A.E. A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix. Biomedical Microdevices 20, 43 (2018) [Link]

 

57. Leblanc-Latour, M., Bryan, C. & Pelling, A.E. Utilizing Social Media and Video Games to Control #DIY Microscopes. PeerJ Comp Sci 3, e139 (2017) [Link]
 

56. Gullekson, C., Cojoc, G., Schurmann, M., Guck, J. & Pelling, A.E. Mechanical mismatch between Ras transformed and untransformed epithelial cells. Soft Matter 13, 8483 (2017) [Link]

55. Chagnon-Lessard, S., Jean-Ruel, H., Godin, M. & Pelling, A.E. Cellular Orientation is Guided by Strain Gradients. Integr Biol 9, 607 (2017) [Link
 

54. Hickey, R. & Pelling, A.E. The Rotation of Mouse Myoblast Nuclei is Dependent on Substrate Elasticity. Cytoskeleton 74, 184 (2017) [Link]
 

54. Haase, K., Shendruk, T.N. & Pelling, A.E. Rapid dynamics of cell-shape recovery in response to local deformations. Soft Matter 13, 567 (2017) [Link]
 

53. Gullekson, C., Walker, M, Harden, J.L. & Pelling, A.E. Mechanodynamics of Unsupported Epithelial Monolayers Grown at an Air-Water Interface. Mol Biol Cell 28, 111 (2017) [Link]
 

52. Hadjiantoniou, S.V., Sean. D., Ignacio, M., Godin, M., Slater G.W. & Pelling, A.E. Physical Confinement Signals Regulate the Organization of Stem Cells in Three Dimensions. J Roy Soc Interface 13, 20160613 (2016) [Link]
 

51. Modulevsky, D.J., Cuerrier, C.M. & Pelling, A.E. Biocompatibility of Subcutaneously Implanted Plant-Derived Cellulose Biomaterials. Plos One 11, e0157894 (2016) [Link]
 

50. Haase, K., Macadangdang, J.K.L., Edrington, C.H., Cuerrier, C.M.,Hadjiantoniou, S., Harden, J.L., Skerjanc, I.S. & Pelling, A.E. Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner. Sci Rep 21300 (2016) [Link]

49. Alshehri, A., Hadjiantoniou, S., Hickey, R., Al-Rekabi, Z., Harden, J., Pelling, A.E., Bhardwaj, R. Selective Cell Adhesion on Femtosecond Laser Microstructured Polydimethylsiloxane. Biomed Mater 11, 015014 (2016) [Link]

48. Ali, S., Wall, I.B., Mason, C., Pelling, A.E. & Veraitch, F.S. The effect of Youngs modulus on mouse embryonic stem cell neuronal differentiation. Acta Biomateriala 25, 253 (2015) [Link]

47. Modulevsky, D., Cuerrier, C.M. & Pelling, A.E. Open Source Biomaterials for Regenerative Medicine. BioCoder 8, 17 (2015) [Link]

 

46. Modulevsky, D. & Pelling, A.E. DIY Open Source Biomaterials. BioCoder 8, 43 (2015) [Link]

 

45. Pelling, A.E. Re-purposing Life in an Anti-disciplinary and Curiosity Driven Context. Leonardo 48, 274 (2015) [Link]

 

44. Haase, K., Al-Rekabi, Z., Guolla, L., Hickey, R., Tremblay, D. & Pelling, A.E. Simultaneous optical and mechanical probes to investigate complex cellular responses to physical cues. Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270I (2015) [Link]

 

43. Haase, K. & Pelling, A.E. Investigating Cell Mechanics with Atomic Force Microscopy. J Roy Soc Interface 12, 20140970 (2015) [Link]

 

42. Haase, K., Al-Rekabi, Z., & Pelling, A.E. Mechanical Cues Direct Focal Adhesion Dynamics. Prog Mol Biol Transl Sci 126, 103 (2014)

 

41. Tremblay, D., Cuerrier, C., Andrzejewski, L., OBrien, E. & Pelling, A.E. A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology. J Vis Exp 88, e51454 (2014) 

 

40. Modulevsky, D.J., Lefebvre, C., Haase, K., Al-Rekabi, Z. & Pelling, A.E. Apple Derived Cellulose Scaffolds for 3D Mammalian Cell Culture . Plos One 9, e97835 (2014)

 

39. Tremblay, D., Chagnon-Lessard, S., Mirzaei, M., Pelling, A.E. & Godin, M. A Microscale Anisotropic Biaxial Cell Stretching Device for Applications in Mechanobiology. Biotech Lett 36, 657 (2014)

 

38. Al-Rekabi, Z., Haase, K. & Pelling, A.E. Microtubules mediate changes in membrane cortical elasticity during contractile activation. Exp Cell Res 322, 21 (2014) 

 

37. Tremblay, D., Andrzejewski, L., Leclerc, A. & Pelling, A.E. Actin and Microtubules Play Distinct Roles in Governing the Anisotropic Deformation of Cell Nuclei in Response to Substrate Strain. Cytoskeleton 70, 837 (2013)

 

36. Haase, K. & Pelling, A.E. The Role of the Actin Cortex in Maintaining Cell Shape. Commun Integr Biol 6, e26714 (2013)

 

35. Al-Rekabi, Z. & Pelling, A.E. Cross talk between matrix elasticity and mechanical force regulates myoblast traction dynamics. Phys Biol 10, 066003 (2013)

 

34. Haase, K. & Pelling, A.E. Resiliency of the Plasma Membrane and Actin Cortex to Large-Scale Deformation. Cytoskeleton 70, 494 (2013)

 

33. Leclerc, A., Tremblay, D., Hadjiantoniou, S., Bukoreshtliev, N.V., Rogowski, J.L., Godin, M. & Pelling, A.E. Three Dimensional Spatial Separation of Cells in Response to Microtopography. Biomaterials 34, 8097 (2013)

 

32. Baset, F., Popov, K., Villafranca, A., Guay, J., Al-Rekabi, Z., Pelling, A.E., Ramunno, L. & Bhardwaj, R. Femtosecond Laser Induced Surface Swelling in Poly-methyl Methacrylate. Optics Exp 21, 12527 (2013)

 

31. Dufrêne, Y.F. & Pelling, A.E. Force Nanoscopy of Cell Mechanics and Cell Adhesion. Nanoscale 5, 4094 (2013)

30. Silberberg, Y.R. & Pelling, A.E. Quantification of Intracellular Mitochondrial Displacements in Response to Nanomechanical Forces. Meth Mol Biol 991, 185 (2013)

 

29. Bukoreshtliev, N.V., Haase, K. & Pelling, A.E. Mechanical Cues in Cellular Signalling and Communication. Cell Tissue Res 352, 77 (2013)

 

28. Cuerrier, C., Chen, Y., Tremblay, D., McNulty, M., Zhao, X., Kennedy, C.R.J., de Belleroche, J., Pelling, A.E. & OBrien, E.R. Chronic Over-expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: A Combined Histological and Mechanical Assessment of Aortic Lesions. Plos One 8, e55867 (2013)

 

27. Modulevsky, D.J., Tremblay, D., Gullekson, C., Bukoreshtliev, N.V. & Pelling, A.E. The Physical Interaction of Myoblasts with the Microenvironment During Remodeling of the Cytoarchitecture. Plos One 7, e45329 (2012)

26. Hadjiantoniou, S., Guolla, L. & Pelling, A.E. Mechanically Induced Deformation and Strain Dynamics in Actin Stress Fibres. Commun Integr Biol 5, 627 (2012)

 

25. Guolla, L., Bertrand, M., Haase, K. & Pelling, A.E. Force Transduction and Strain Dynamics in Actin Stress Fibres in Response to Nanonewton Forces. J Cell Science 125, 603 (2012)

 

24. Wang, J & Pelling, A.E. An Approach to Visualize the Deformation of the Intermediate Filament Cytoskeleton in Response to Locally Applied Forces. ISRN Cell Biology 2012, 513546 (2012)

 

23. Hemsley, A.L., Hernandez, D., Pelling, A.E. & Veraitch, F.S. Precisely delivered nano-mechanical forces induce blebbing in undifferentiated mouse embryonic stem cells. Cell Health and Cytoskeleton 3, 23 (2011)

 

22. Wang, J. & Pelling, A.E. Cell Sheet Integrity and Nanomechanical Breakdown During Programmed Cell Death. Med Biol Eng Comput 48, 1015 (2010)

 

21. Silberberg, Y.S., Yakubov, G.E., Horton, M.A. & Pelling, A.E. Cell Nanomechanics and Focal Adhesions are Regulated by Retinol and Conjugated Linoleic Acid in a Dose Dependent Manner. Nanotechnology 20, 285103 (2009)

 

20. Pelling, A.E., Veraitch, F.S., Chu, C.P.K., Mason, C. & Horton, M.A. Mechanical Dynamics of Single Cells During Early Apoptosis. Cell Motil Cytoskeleton 66, 409 (2009)

 

19. Hogan, C., Dupre-Crochet, S., Norman, M., Kajita, M., Zimmermann, C., Pelling, A.E., Piddini, E., Baena-Lopez, A., Vincent, J., Itoh, Y., Hosoya, H., Pichaud, F. & Fujita, Y. Characterization of the Interface Between Normal and Transformed Epithelial Cells. Nature Cell Biol 11, 460 (2009)

 

18. Pelling, A.E., Wilkinson, P.R., Stringer, R.P. & Gimzewski, J.K. Dynamic Mechanical Oscillations During Metamorphosis of the Monarch Butterfly. J Roy Soc Interface 6, 29 (2009)

 

17. Silberberg, Y.R., Pelling, A.E., Yakubov, G.E., Crum, W.R., Hawkes, D.J. & Horton, M.A. Tracking Displacements of intracellular Organelles in Response to Nanomechanical Forces. Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on. 1335-1338 (2008)

 

16. Kunda, P., Pelling, A.E., Liu, T. & Baum, B. Moesin Controls Cortical Rigidity, Cell Rounding and Spindle Assembly During Mitosis. Curr Biol 18, 91 (2008)

 

15. Silberberg, Y.R., Pelling, A.E., Yakubov, G.E., Crum, W.R., Hawkes, D.J. & Horton, M.A. Mitochondrial Displacements in Response to Nanomechanical Forces. J Mol Recognit 21, 30 (2008)

 

14. Pelling, A.E. & Horton, M.A. An Historical Perspective on Cell Mechanics. Pflügers Archiv Eur J Physiol 456, 3 (2008)

 

13. Pelling, A.E., Veraitch, F.S., Chu, C.P.K., Nicholls, B.M., Hemsley, A.L., Mason, C. & Horton, M.A. Mapping Correlated Membrane Pulsations and Fluctuations in Human Cells. J Mol Recognit 20, 467 (2007)

 

12. Pelling, A. E., Dawson, D. W., Carreon, D. M., Christiansen, J. J., Shen, R. R., Teitell, M. A. & Gimzewski, J. K. Distinct Contributions of Microtubule Subtypes to Cell Membrane Shape and Stability. Nanomedicine 3, 43 (2007)

 

11. Haupt, B.J., Pelling, A.E. & Horton, M.A. Integrated Confocal and Scanning Probe Microscopy for Biomedical Research. ScientificWorldJournal 6, 1609 (2006)

 

10. Pelling, A.E., Li, Y., Cross, S.E., Castaneda, S., Shi, W. & Gimzewski, J.K. Self-Organized and Highly Ordered Domains within Swarms of Myxococcus xanthus. Cell Motil Cytoskeleton 63, 141 (2006)

 

9. Cross, S.E., Kreth, J., Zhu, L., Qi, F., Pelling, A.E., Shi, W. & Gimzewski, J.K. Atomic Force Microscopy Study of the Structure-Function Relationships of the Biofilm-Forming Bacterium Streptococcus mutans. Nanotechnology 17, S1 (2006)

 

8. Han, T.H., Pelling, A.E., Jeon, T., Gimzewski, J.K. & Liao, J. Erythrocyte Nitric Oxide Transport Reduced by a Submembrane Cytoskeletal Barrier. Biochim Biophys Acta 1726, 336 (2005)

 

7. Pelling, A.E., Sehati, S., Gralla, E.B. & Gimzewski, J.K. Time Dependence of the Frequency and Amplitude of the Local Nanomechanical Motion of Yeast. Nanomedicine 1, 178 (2005)

 

6. Pelling, A.E., Li, Y., Shi, W. & Gimzewski, J.K. Nanoscale Visualization and Characterization of Myxococcus xanthus Cells with Atomic Force Microscopy. Proc Natl Acad Sci USA 102, 6484 (2005)

 

5. Li, Y., Lux, R., Pelling, A.E., Gimzewski, J.K. & Shi, W. Analysis of Type IV Pilus and Its Associated Motility in Myxococcus xanthus Using an Antibody Reactive with Native Pilin and Pili. Microbiology 151, 353 (2005)

 

4. Rong, W., Pelling, A.E., Ryan, A., Gimzewski, J.K. & Friedlander, S.K. Complementary TEM and AFM Force Spectroscopy to Characterize the Nanomechanical Properties of Nanoparticle Chain Aggregates. Nano Lett 4, 2287 (2004)

 

3. Sattin, B.D., Pelling, A.E. & Goh. M.C. DNA Base Pair Resolution by Single Molecule Force Spectroscopy. Nuc Acids Res 32, 4876 (2004)

 

2. Pelling, A.E., Sehati, S., Gralla, E.B., Valentine, J.S. & Gimzewski, J.K. Local Nanomechanical Motion of the Cell Wall of Saccharomyces cerevisiae. Science 304, 1147 (2004)

 

1. Pezacki, J.P., Pelling, A. & Kluger, R. S-Nitrosylation of Cross-Linked Hemoglobins at b-Cysteine-93: Stabilized Hemoglobins as Nitric Oxide Sources. J Am Chem Soc 122, 10734 (2000)

Books and Book Chapters

10. Cuerrier, C. & Pelling, A.E. eds. Cells, Forces and the Microenvironment. Singapore: Pan Stanford Publishing, 387 pages (2015).

 

9. Pelling, A.E. Re-purposing the Behaviour and Motion of Living Cells in an Anti-Disciplinary and Curiosity Driven Context. Bureaud, A., Malina, R.F. & Whiteley, L. eds. META-Life. Biotechnologies, Synthetic Biology, ALife and the Arts. Cambridge: Leonardo MIT Press Journals (2014).

 

8. Haase, K., Tremblay, D. & Pelling, A.E. Mechanotransduction: Probing its Mechanisms at the Nanoscale using the Atomic Force Microscope. Takeyasu, K. ed. Atomic Force Microscopy in Nanobiology. Singapore: Pan Stanford Publishing, pp. 379-422 (2014).

 

7. Al-Rekabi, Z., Tremblay, D. Haase, K., Leask, R.L. & Pelling, A.E. Computational and Experimental Approaches to Cellular and Subcellular Tracking at the Nanoscale. Musa, S.M. ed. Computational Nanotechnology: Modeling and Applications with MATLAB. New York: CRC Press, pp.333-361 (2011).

 

6. Silberberg, Y.R., Guolla, L. & Pelling, A.E. Investigating Mammalian Cell Nanomechanics with Simultaneous Optical and Atomic Force Microscopy. Dufrene, Y.F. ed. Life at the Nanoscale: Atomic Force Microscopy of Live Cells. Singapore: Pan Stanford Publishing, pp.375-401 (2011).

 

5. Al-Rekabi, Z., Harden, J.L. & Pelling, A.E. Cellular Nanomechanics in Nanomedicine. In Bartul, Z. & Trenor, J. eds.Advances in Nanotechnology Volume 2. New York: Nova Science Publishers, pp.275-296 (2010).

 

4. Niemetz, A. & Pelling, A.E. Dark Side of the Cell III. In Kwong, J., To, D. & Ng, N. eds. Transient Creatures. Hong Kong: Microwave, pp.80-83 (2008).

 

3. Pelling, A.E., Nicholls, B.M., Silberberg, Y.S. & Horton, M.A. Approaches for Investigating Mechanobiologial Dynamics in Living Cells with Combined Fluorescence and Atomic Force Microscopies. In Méndez-Vilas, A. & Díaz, J. eds. Modern Research and Educational Topics on Microscopy. Badajoz: Formatex, pp.3-10 (2007).

 

2. Pelling, A.E. & Niemetz, A. Cellular Sounds. In Mol, J.V. ed. The Nano Research. Ad!dict Inspiration Book #27. Brussles: Ad!dict Lab, pp.24-27 (2007).

1. Niemetz, A. & Pelling, A.E. Singende Zellen, Kunst, Wissenschaft und das Bauschen dazwischen. In: Könches, B., & Weibel, P. eds. unSICHTBARes Kunst und Wissenschaft. Bern: Benteli Verlag, pp.322-337 (2005).