20170607_015137
AFM tip + cells copy
WholeAppleSeeding_ByDanielModulevsky
512-Test003.nd2 - C=0.tif.display3
TED2016_PhotoByRyanLash_4
TED2016_PhotoByRyanLash_1
TED2016_PhotoByRyanLash_3
RePurposed46 - Image Credit City of Ottawa
steak
PhotoByBonnieFindley_20160318-BF-DTC-ANDREW-PELLING-96
SEM_MouseCellsOnDecellularizedAppleScaffold_PhotoByDanielModulevskyAndTristanMatheson
RePurposed46 Close Up - Image Credit Andrew Pelling
PhotoByBonnieFindley_20160318-BF-DTC-ANDREW-PELLING-62
Photo by Peter Thornton - University of Ottawa-Pelling-TED-206-1-9
PhotoByBonnieFindley_20160318-BF-DTC-ANDREW-PELLING-19
Pelling-lab-6
Pelling-lab-7
Life in 2030_095s
IMG_9198
IMG_4709
mascot
HeLa_On_MiniFigs - Image Credit Andrew Pelling
DSC02129
DSC02125
HeLa_Cells_On_MiniFig_Hand - Image Credit Andrew Pelling
ears_photo by Andrew Pelling
DSC02124
DSC02122
DSC02056
DSC02028
DSC02034
DSC02026
DSC01818
DSC01606
DSC00996
DSC00971-cdrom
DSC00713
DSC00565
AP_asparagus_PhotoByAndrewPelling
DSC00538
AppleEars_Photo by Alexis Williams
DSC00526
DSC00513
Biofabricate 2016-Spiderwort Incubator3_PhotoByAndrewPelling
AppleWithHumanCells_PhotoByAndrewPelling
Biofabricate 2016-Spiderwort Incubator2_PhotoByDanielElm
20170607_015137
AFM tip + cells copy
WholeAppleSeeding_ByDanielModulevsky
512-Test003.nd2 - C=0.tif.display3
TED2016_PhotoByRyanLash_4
TED2016_PhotoByRyanLash_1
TED2016_PhotoByRyanLash_3
RePurposed46 - Image Credit City of Ottawa
steak
PhotoByBonnieFindley_20160318-BF-DTC-ANDREW-PELLING-96
SEM_MouseCellsOnDecellularizedAppleScaffold_PhotoByDanielModulevskyAndTristanMatheson
RePurposed46 Close Up - Image Credit Andrew Pelling
PhotoByBonnieFindley_20160318-BF-DTC-ANDREW-PELLING-62
Photo by Peter Thornton - University of Ottawa-Pelling-TED-206-1-9
PhotoByBonnieFindley_20160318-BF-DTC-ANDREW-PELLING-19
Pelling-lab-6
Pelling-lab-7
Life in 2030_095s
IMG_9198
IMG_4709
mascot
HeLa_On_MiniFigs - Image Credit Andrew Pelling
DSC02129
DSC02125
HeLa_Cells_On_MiniFig_Hand - Image Credit Andrew Pelling
ears_photo by Andrew Pelling
DSC02124
DSC02122
DSC02056
DSC02028
DSC02034
DSC02026
DSC01818
DSC01606
DSC00996
DSC00971-cdrom
DSC00713
DSC00565
AP_asparagus_PhotoByAndrewPelling
DSC00538
AppleEars_Photo by Alexis Williams
DSC00526
DSC00513
Biofabricate 2016-Spiderwort Incubator3_PhotoByAndrewPelling
AppleWithHumanCells_PhotoByAndrewPelling
Biofabricate 2016-Spiderwort Incubator2_PhotoByDanielElm

about

Inside the Pelling Lab

The Lab is interested in creating living, functional, biological objects that do not exist in nature. By physically manipulating and re-purposing living systems the Lab has discovered an astonishing ability of cells to deliberately adapt and respond to highly artificial and unusual stimuli.

What do we do?

We are interested in understanding the fundamental mechanisms through which cells sense and integrate physical information. We do this by building devices that employ nano- and micro-scale fingers, lasers, matrices and textures to literally poke, feel, stretch and confine cells while we watch how they respond.

 

On the other hand, we are also interested in how we might use such physical stimuli to manipulate, re-purpose and control living cells. Physical inputs might include exposing cells to mechanical forces, controlling the shape of their surroundings or simply growing cells in environments in which they are not normally found.

 

None of these approaches require genetic manipulation or pharmaceuticals; we simply change the physical environment to direct cellular behaviours. We have found that living cells are surprisingly adaptable to a wide variety of environments and physical stimuli that they have not evolved to cope with. This raises numerous questions about how cells are able to deal with such extremes.


 

The Lab is heavily informed by the biological and physical sciences, DIY, hacking, engineering, design and arts. Utilizing a combination of cell biology, molecular biology, biophysical tools, device design and computational approaches we aim to understand the fundamental mechanisms that allow cells to sense and respond to physical cues.

A variety of tools allow us to probe the force transduction and response pathways of single cells, multi-cellular aggregates and tissues at local and global scales while simultaneously controlling their mechanical, biochemical and physiological environments. Our work is enhanced by the diversity of our people and numerous collaborations across all disciplines.

Pelling Lab supporters & Partners

Show More

The Pelling Lab

University of Ottawa

Department of Physics

STEM Complex

150 Louis Pasteur

Ottawa, ON K1N6N5

Canada

  • Twitter - Grey Circle
  • Instagram - Grey Circle

Copyright © 2017 Pelling Lab